Nicole Romeo spent the first part of her career in Australia and she won the WNBL with Canberra in the 2009/10 season, was WNBL Finalist with Townsville in the 2012/13 season and played also for Melbourne.

Nicole also had experiences in the QBL, averaring 26.1 points per game with Rockhamption in 2011, and in the SEABL, averaging 21.3 points per game with Frankston in 2013 and 16.9 points and 4.7 assists in 2014.

Nicole Romeo started her overseas career in the 2014/15 season and she signed in Germany with Wasserburg and won both the German League and the German Cup, averaging 7.2 points in 16 minutes per game, having good performances against Avides (10 points 7 assists +20 efficiency), Donau Ries (17 points 6 assists +19 efficiency) and Chemnitz (16 points +19 efficiency).

In the 2015 summer, Nicole Romeo signed in Australia with Nunawading and she averaged 14.1 points 5.3 rebounds and 3.4 asissts per game with 38% from the three point line.

In the 2015/16 season, Nicole Romeo signed in Spain with Cadí La Seu and she averaged 10.9 points in 21 minutes per game, finishing in Liga Femenina 5th position. Nicole had great games against Azkoitia (22 points +28 efficiency), CREF (21 points) and Ferrol (18 points in 16 minutes), being also the best free throw shooter in the competition (97.6%).

In the 2016 summer, Nicole Romeo signed in Australia with Warrandyte Venom and she averaged 24.4 points, 6 rebounds and 3.8 assists per game.

Nicole signed in Spain again during the 2016/17 season and she averaged 13.5 points, 4.2 rebounds and 2.5 assists per game playing for Campus Promete, shining against Araski (23 points +26 efficiency), Girona (22 points in both games), Zamarat (22 points) and Al-Qázeres (20 points).

In the 2017 summer, Nicole Romeo signed in Australia wih the Sandringham Sabres and she averaged 21.3 points, 5 rebounds and 5 assists per game.

Nicole Romeo signed with Uni Girona in the 2017/18 season and she reached the Spanish Liga Femenina, Queen´s Cup and Spanish Supercup Finals and also the Eurocup Quarterfinals.

With Uni Girona, Nicole Romeo averaged 7.3 points, 2.1 rebounds, 2 assists and +7.3 efficiency in 19 minutes per game in League and 10.2 points, 2.4 rebounds, 3.8 assists and +9.7 efficiency in 23 minutes per game in the Eurocup, shining against Olympiacos with 22 points and against Cegledi with 21 points in 23 minutes.

In the 2018/19 season, Nicole Romeo signed in Turkey with Canik and she averaged 16.1 points, 4.6 rebounds and 4.3 assists per game.

In January 2019, Nicole Romeo signed in Italy with Ragusa and she averaged extraordinary 11.8 points, 2.1 rebounds and 2.8 assists in 23 minutes per game with excellent 54% from the field, 42% in three pointers and 95% in free throws to win the Italian Cup (scoring 22 points in 23 minutes against Schio in Semifinals) and reaching the Italian League Final.

In the 2019/20 season, Nicole Romeo re-signed with Ragusa and she averaged 12.1 points and 3.7 assists per game with 39% from the 3 point line.

Nicole Romeo extended with Ragusa for the 2020/21 season and she averaged 11.8 points (45% 3P), 3.5 assists and +13.3 efficiency per game.

In the 2021/22 season, Nicole Romeo re-signed with Ragusa and she averaged 12.3 points, 2.4 rebounds and 3.9 assists per game with excellent shooting %.

With the Italian National Team, in November 2021, Nicole Romeo averaged 15.5 points in 21 minutes per game.

Nicole re-signed with Ragusa in the 2022/23 season and she averaged 10.1 points, 3 rebounds and 3.4 assists per game with 37% from the 3 point line.

In the 2023/24 season, Nicole Romeo signed with Rome and averaged 11.9 points and 4 assists per game with 50% from the field and 37.8% in three pointers.